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Canagliflozin + Metformin

Canagliflozin + Metformin is a combination medication used to treat type 2 diabetes. Canagliflozin is a sodium-glucose cotransporter-2 (SGLT2) inhibitor, while Metformin is a biguanide. This combination works by helping the kidneys remove glucose from the bloodstream and lowering the amount of glucose produced by the liver. It is typically used in combination with diet and exercise to help control blood sugar levels in adults with type 2 diabetes.

Depletion Beneficial Side Effects Recommendation

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Depletes

Prolonged use of Canagliflozin + Metformin can impact 4 essential nutrients.

Folic Acid

Vitamin B12

Thiamine Vitamin B1

CoQ10

Also Affects:

Taurine

Chromium Polynicotinate

Gymnema sylvestre

Alpha Lipoic Acid

Health Impact

Canagliflozin + Metformin-induced nutrient depletion can lead to a range of health problems

High Homocysteine & Vascular Risk

Folate-Related Megaloblastic Anemia

B12-Related Megaloblastic Anemia

B12 Neuropathy & Cognitive Decline

Statin-Related Muscle Pain & Fatigue

Low Mitochondrial Energy & Antioxidant Defense

Side Effects

Common side effects of Canagliflozin + Metformin, some of which may be related to nutrient depletion

Review

Get Support

We’ve provided a carefully curated list of vetted, recommended third-party supplements, offering alternative options that meet our high standards for quality, purity, and effectiveness.

Folate

by Pure Encapsulations

Vitamin B12 Methylcobalamin

by Pure Encapsulations

COQ 10 (as Ubiquinone)

by Life Extension

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