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Pioglitazone + Metformin

Pioglitazone + Metformin is a combination medication used to treat type 2 diabetes. Pioglitazone is a thiazolidinedione that helps improve insulin sensitivity, while metformin is a biguanide that helps lower blood sugar levels. This combination medication helps control blood sugar levels in individuals with type 2 diabetes.

Depletion Beneficial Side Effects Recommendation

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Depletes

Prolonged use of Pioglitazone + Metformin can impact 4 essential nutrients.

Thiamine Vitamin B1

Folic Acid

Vitamin B12

CoQ10

Also Affects:

Taurine

Chromium Polynicotinate

Gymnema sylvestre

Alpha Lipoic Acid

Health Impact

Pioglitazone + Metformin-induced nutrient depletion can lead to a range of health problems

High Homocysteine & Vascular Risk

Folate-Related Megaloblastic Anemia

B12-Related Megaloblastic Anemia

B12 Neuropathy & Cognitive Decline

Statin-Related Muscle Pain & Fatigue

Low Mitochondrial Energy & Antioxidant Defense

Side Effects

Common side effects of Pioglitazone + Metformin, some of which may be related to nutrient depletion

Review

Get Support

We’ve provided a carefully curated list of vetted, recommended third-party supplements, offering alternative options that meet our high standards for quality, purity, and effectiveness.

Folate

by Pure Encapsulations

Vitamin B12 Methylcobalamin

by Pure Encapsulations

COQ 10 (as Ubiquinone)

by Life Extension

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